IPV Perpetrator Groups: Client Engagement, and the Role of Facilitators.

Based on the emerging literature being developed in Motivational Interviewing that suggests certain group process factors and facilitator attributes predict treatment outcomes, this study sought to investigate the relationship between both client and facilitator ratings of the batterer intervention group experience. This study presents data from 16 group facilitators drawn from five agencies and 175 clients being served by these facilitators. The data gathered included both facilitator ratings of clients (i.e., Group Engagement Measure-GEM) and client ratings of facilitators and the group experience (i.e., Client Rating of Facilitator-CRF, Client Perceived Benefits of Group-CPBG). Results indicate that facilitators rated clients as being engaged in the group process across all the domains assessed by the GEM and that clients viewed the facilitators and group experiences favorably as assessed by the CRF and CPBG. There was no significant correlation between the GEM and CRF or the GEM and CPBG, but there was a strong, positive correlation between the CRF and CPBG. The results here support previous research findings suggesting a strong correlation between client engagement in the therapeutic process, based on their perception of the facilitator, and their perceived benefits of the group experience. Implications of the findings for improving empirical investigations of the batterer intervention group experience were explored and discussed.

The Pursuit of Research-supported Treatment in Batterer Intervention: The Role of Professional Licensure and Theoretical Orientation for Duluth and CBT Programs.

PURPOSE: The purpose of this study was to understand the importance of research-supported practice for batterer intervention programs. METHODS: This study applied descriptive statistics and chi-square analyses to a novel dataset from the Domestic Violence Perpetrator Treatment Survey (N = 411). This was a 69-item survey developed by domestic violence providers and researchers to understand the role of research-supported practice in the treatment of intimate partner violence (IPV). RESULTS: This study found statistically significant differences between Duluth oriented programs and Cognitive Behavioral Therapy (CBT) oriented programs with respect to the importance of research-supported practices and motivational interviewing, a strategy found effective in treatment of IPV by extant research. DISCUSSION: There appears to have been an evolution among practitioners toward more eclecticism, and an acknowledgment that programs should be research-supported. CONCLUSION: Implications of this study for education and treatment are discussed.

Associations Between Attachment Insecurities and Psychological Violence in a Sample of Court-Mandated Batterers.

We conducted a survey-based study looking at the associations among attachment insecurities (anxiety and avoidance), relationship functioning, and psychological domestic violence. We looked at three relationship functioning variables (i.e., anger management, communication, and conflict resolution) and three domestic psychological violence variables (i.e., derogation and control, jealous-hypervigilance, and threats-control of space). Data were collected from 76 male and 21 female court-mandated batterers. Participants completed the self-report measures of attachment insecurities, relationship functioning, and psychological domestic violence-related variables. Overall, attachment insecurities were negatively associated with relationship functioning and positively associated with psychological domestic violence outcomes. Among the whole sample, attachment anxiety correlated positively with derogation and control and with jealous-hypervigilance. There were also differential attachment associations by gender. Attachment anxiety correlated positively with threats of controlling space only among men, and with derogation and control and jealous-hypervigilance only among women. Finally, avoidance correlated negatively with communication only among women. Overall, this pattern of results is consistent with predictions derived from attachment theory: attachment insecurities are associated with poor relationship functioning and high rates of domestic violence.

Velcro-Inspired SiC Fuzzy Fibers for Aerospace Applications.

The most recent and innovative silicon carbide (SiC) fiber ceramic matrix composites, used for lightweight high-heat engine parts in aerospace applications, are woven, layered, and then surrounded by a SiC ceramic matrix composite (CMC). To further improve both the mechanical properties and thermal and oxidative resistance abilities of this material, SiC nanotubes and nanowires (SiCNT/NWs) are grown on the surface of the SiC fiber via carbon nanotube conversion. This conversion utilizes the shape memory synthesis (SMS) method, starting with carbon nanotube (CNT) growth on the SiC fiber surface, to capitalize on the ease of dense surface morphology optimization and the ability to effectively engineer the CNT-SiC fiber interface to create a secure nanotube-fiber attachment. Then, by converting the CNTs to SiCNT/NWs, the relative morphology, advantageous mechanical properties, and secure connection of the initial CNT-SiC fiber architecture are retained, with the addition of high temperature and oxidation resistance. The resultant SiCNT/NW-SiC fiber can be used inside the SiC ceramic matrix composite for a high-heat turbo engine part with longer fatigue life and higher temperature resistance. The differing sides of the woven SiCNT/NWs act as the "hook and loop" mechanism of Velcro but in much smaller scale.

A Gender Comparison of Motivations for Physical Dating Violence Among College Students.

There are limited empirical investigations that directly compare men and women's motivations, or reasons, for perpetrating physical dating violence (DV). In an attempt to further understand whether men and women have similar or different motives for physical DV, the purpose of the current study was to conduct a gender comparison of motives in a sample of male (n = 163) and female (n = 319) college students. Motivations for physical DV were classified according to seven broad categories proposed by Langhinrichsen-Rohling and colleagues: (a) power/control, (b) self-defense, (c) expression of negative emotion (e.g., anger), (d) communication difficulties, (e) retaliation, (f) jealousy, and (g) other (e.g., because it was sexually arousing, the influence of alcohol, the influence of drugs). The prevalence of physical violence perpetration in the overall sample was 29.4%. Results indicated that communication difficulties and self-defense were among the most frequently endorsed motive categories for both male and female perpetrated DV. In addition, results demonstrated gender similarity in all of the examined motive categories. Research and clinical implications are discussed.

The CAT: A Gender-Inclusive Measure of Controlling and Abusive Tactics.

Research has consistently found that partner violence, defined as physical abuse between married, cohabitating, or dating partners, is not the only type of abuse with long-term deleterious effects on victims. Male and female victims alike report that emotional abuse, along with controlling behaviors, are often as or more traumatic. Existing instruments used to measure emotional abuse and control have either been limited to male-perpetrated behaviors, as conceived in the well-known Duluth "Power and Control" wheel, or field tested on dating or general population samples. This study discusses the genesis and evolution of a gender-inclusive instrument, the Controlling and Abusive Tactics (CAT) Questionnaire, which was field tested on males and females with both a clinical and general population sample. For perpetration, a preliminary comparison across gender found no significant differences across gender for the great majority of items, with women reporting significantly higher rates on 9 items, and men reporting significantly higher rates on 6 items. Women reported higher rates of received abuse than men on 28 of 30 items in which gender differences were found to be significant, but both males and females reported higher victimization than perpetration rates on all items. Exploratory and confirmatory factor analyses resulted in the CAT-2, a valid and reliable instrument appropriate for clinical use by treatment providers as well as for research purposes.

Motivations for intimate partner violence in men and women arrested for domestic violence and court referred to batterer intervention programs.

Research has attempted to elucidate men and women's proximal motivations for perpetrating intimate partner violence (IPV). However, previous research has yet to clarify and resolve contention regarding whether motives for IPV are gender-neutral or gender specific. Thus, the purpose of this present study was to compare motives for physical IPV perpetration among a sample of men (n =90) and women (n =87) arrested for domestic violence and court-referred to batterer intervention programs. Results demonstrated that the most frequently endorsed motives for IPV by both men and women were self-defense, expression of negative emotions, and communication difficulties. With the exception of expression of negative emotions and retaliation, with women endorsing these motives more often than men, there were no significant differences between men and women's self-reported reasons for perpetrating physical aggression. The implications of these findings for future research and intervention programs are discussed.

Cathepsin B regulates the appearance and severity of mercury-induced inflammation and autoimmunity.

Susceptibility and resistance to systemic autoimmunity are genetically regulated. This is particularly true for murine mercury-induced autoimmunity (mHgIA) where DBA/2J mice are considered resistant to disease including polyclonal B cell activation, autoantibody responses, and immune complex deposits. To identify possible mechanisms for the resistance to mHgIA, we exposed mHgIA sensitive B10.S and resistant DBA/2J mice to HgCl2 and assessed inflammation and pro-inflammatory responses at the site of exposure and subsequent development of markers of systemic autoimmunity. DBA/2J mice showed little evidence of induration at the site of exposure, expression of proinflammatory cytokines, T cell activation, or autoantibody production, although they did exhibit increased levels of total serum IgG and IgG1. In contrast B10.S mice developed significant inflammation together with increased expression of inflammasome component NLRP3, proinflammatory cytokines IL-1ß, TNF-α, and IFN-γ, hypergammaglobulinemia, splenomegaly, CD4(+) T-cell activation, and production of autoantibodies. Inflammation in B10.S mice was associated with a selective increase in activity of cysteine cathepsin B but not cathepsins L or S. Increased cathepsin B activity was not dependent on cytokines required for mHgIA but treatment with CA-074, a cathepsin B inhibitor, led to transient reduction of local induration, expression of inflammatory cytokines, and subsequent attenuation of the systemic adaptive immune response. These findings demonstrate that sensitivity to mHgIA is linked to an early cathepsin B regulated inflammatory response which can be pharmacologically exploited to abrogate the subsequent adaptive autoimmune response which leads to disease.

Definition of IFN-γ-related pathways critical for chemically-induced systemic autoimmunity.

IFN-γ is essential for idiopathic and murine mercury-induced systemic autoimmunity (mHgIA), and heterozygous IFN-γ(+/-) mice also exhibit reduced disease. This suggests that blocking specific IFN-γ-related pathways that may only partially inhibit IFN-γ production or function will also suppress autoimmunity. To test this hypothesis, mice deficient in genes regulating IFN-γ expression (Casp1, Nlrp3, Il12a, Il12b, Stat4) or function (Ifngr1, Irf1) were examined for mHgIA susceptibility. Absence of either Ifngr1 or Irf1 resulted in a striking reduction of disease, while deficiency of genes promoting IFN-γ expression had modest to no effect. Furthermore, both Irf1- and Ifng-deficiency only modestly reduced the expansion of CD44(hi) and CD44(hi)CD55(lo) CD4(+) T cells, indicating that they are not absolutely required for T cell activation. Thus, there is substantial redundancy in genes that regulate IFN-γ expression in contrast to those that mediate later signaling events. These findings have implications for the therapeutic targeting of IFN-γ pathways in systemic autoimmunity.

Emergency management of chronic pain and drug-seeking behavior: an alternate perspective.

Pain is one of the most prevalent conditions treated by Emergency Physicians, although it remains contested how to interpret, measure, and treat this condition. In particular, there is controversy over how to identify and treat patients with chronic under-treated pain and those who are potentially malingering (drug-seeking). This article discusses currently accepted paradigms for treating potentially malingering patients, difficulties some communities may have when these paradigms are applied, and the results of implementing pain treatment guidelines that limit opioid use. Systematically limiting opioids via these guidelines was not associated with a decrease in overall patient satisfaction, patient satisfaction with pain management, overall volume, or volume of patients with potential drug-seeking diagnoses. Emergency Physicians' perception of quality of care delivered, as well as job satisfaction, increased after implementation of the guidelines.

Perceptions of motives in intimate partner violence: expressive versus coercive violence.

This study examined perceptions of motives in the perpetration of intimate partner violence. Respondents (N = 401) of diverse professions read three vignettes and indicated their perception of the aggressor's motive (from 1 = Exclusively Expressive; 5 = Exclusively Coercive). Half of respondents read vignettes describing male-perpetrated violence against a female partner; the other half, female-perpetrated violence against a male partner. Overall, male-perpetrated aggression was seen as more coercive than female-perpetrated aggression, particularly by shelter workers and victim advocates. Further analyses revealed that men generally gave higher ratings than women, and that women rated female-perpetrated aggression as less coercive than male-perpetrated aggression. In contrast, men did not differ in their ratings of male versus female perpetration. Implications are discussed with respect to the assessment and treatment of partner violence.

Formation of GW bodies is a consequence of microRNA genesis.

GW bodies (GWBs), or mammalian P bodies, proposed to be involved in messenger RNA storage and/or degradation, have recently been linked to RNA interference and microRNA (miRNA) processing. We report that endogenous let-7 miRNA co-precipitates with the GW182 protein complex. In addition, knockdown of two proteins, Drosha and its protein partner DGCR8, which are vital to the generation of mature miRNA, results in the loss of GWBs. Subsequent introduction of short interference RNA specific to lamin A/C is accompanied by reassembly of GWBs and concurrent knockdown of lamin A/C protein. Taken together, these studies show that miRNAs are crucial components in GWB formation.

GW bodies, microRNAs and the cell cycle.

GW bodies (GWBs) are cytoplasmic foci initially identified through the use of an autoimmune serum targeting the marker protein, GW182. GWBs were first considered as both storage centers for a specific subset of mRNAs and degradation sites for mRNAs. Interestingly, they are known to vary in size and number throughout the cell cycle and are largest in size and most abundant in number during the late S and G2 phases. Recent studies have linked RNA interference to GWBs, in that disruption or disassembly of GWBs was demonstrated to impair siRNA and miRNA silencing activity. As miRNAs are implicated in the regulation of cell cycle progression and cell proliferation, it is very likely that GWBs, the critical intracellular structures for miRNA function, may very well be also linked to this cellular process.

Disruption of GW bodies impairs mammalian RNA interference.

The GW182 RNA-binding protein was initially shown to associate with a specific subset of mRNAs and to reside within discrete cytoplasmic foci named GW bodies (GWBs). GWBs are enriched in proteins that are involved in mRNA degradation. Recent reports have shown that exogenously introduced human Argonaute-2 (Ago2) is also enriched in GWBs, indicating that RNA interference function may be somehow linked to these structures. In this report, we demonstrate that endogenous Ago2 and transfected small interfering RNAs (siRNAs) are also present within these same cytoplasmic bodies and that the GW182 protein interacts with Ago2. Disruption of these cytoplasmic foci in HeLa cells interferes with the silencing capability of a siRNA that is specific to lamin-A/C. Our data support a model in which GW182 and/or the microenvironment of the cytoplasmic GWBs contribute to the RNA-induced silencing complex and to RNA silencing.

Fragmentation of Golgi complex and Golgi autoantigens during apoptosis and necrosis.

Anti-Golgi complex autoantibodies are found primarily in patients with Sjögren's syndrome and systemic lupus erythematosus, although they are not restricted to these diseases. Several Golgi autoantigens have been identified that represent a small family of proteins. Common features of all Golgi autoantigens appear to be their distinct structural organization of multiple alpha-helical coiled-coil rods in the central domains flanked by non-coiled-coil N-termini and C-termini, and their localization to the cytoplasmic face of Golgi cisternae. Many autoantigens in systemic autoimmune diseases have distinct cleavage products in apoptosis or necrosis and this has raised the possibility that cell death may play a role in the generation of potentially immunostimulatory forms of autoantigens. In the present study, we examined changes in the Golgi complex and associated autoantigens during apoptosis and necrosis. Immunofluorescence analysis showed that the Golgi complex was altered and developed distinctive characteristics during apoptosis and necrosis. In addition, immunoblotting analysis showed the generation of antigenic fragments of each Golgi autoantigen, suggesting that they may play a role in sustaining autoantibody production. Further studies are needed to determine whether the differences observed in the Golgi complex during apoptosis or necrosis may account for the production of anti-Golgi complex autoantibodies.

Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera.

OBJECTIVE: To characterize the 15-kd human SmD-like autoantigen and its associated proteins previously shown to be recognized by IgM antibodies in patients with Epstein-Barr virus (EBV)-induced infectious mononucleosis. METHODS: The full-length complementary DNA for the 15-kd protein was expressed as recombinant protein and analyzed for reactivity using biochemical analysis and immunoprecipitation (IP). RESULTS: The 15-kd protein was determined to be the human like-Sm protein LSm4 (hLSm4). Rabbit antibody raised against the C-terminal polypeptide immunoprecipitated a 68-kd complex composed of LSm4 together with a group of smaller proteins ranging in size from 6.5 to 14 kd, consistent with the reported heptameric LSm complexes involved in U4/U6 duplex formation and messenger RNA (mRNA) decapping/degradation. About 80% of all anti-Sm sera from patients with systemic lupus erythematosus (SLE) recognized the hLSm4 in vitro translated product, while 6.7% (29 of 434) immunoprecipitated from cell extracts hLSm4 together with the other members of the hLSm complex. Four sera (0.92%) showed apparently exclusive reactivity to the hLSm complex in the absence of reactivity to Sm core proteins in the IP assay. CONCLUSION: These findings document that while IgM, but not IgG, autoantibodies to LSm4 were found in sera from patients with EBV infection, IgG autoantibodies to hLSm4 are detected in a large number of anti-Sm-positive sera from patients with SLE. Importantly, in a small number of anti-Sm sera the LSm complex can be recognized independently of the Sm core protein antigens. Our data introduce the concept that "Sm" autoantigens include Sm as well as LSm complexes involved in the maturation and degradation of mRNA.